Changes to the public benefit requirement under the Charities Act 2006 Essay

Changes to the open advantage necessity under the Charities Act 2006 have changed the law in the territory of magnanimous trusts. Talk about - Essay Example Alastair Hudson states ‘A noble cause is characterized in the Charities Act 2006 as being ‘an foundation which built up for beneficent purposes only’ and which tumbles to be dependent upon the control of the High Court in the activity of its purview regarding charities.’1 Before the demonstration was executed, there were four altruistic purposes known as heads. These heads are the progression of training, the headway of religion, the alleviation of neediness and the advantage of the network. The new demonstration of 2006 expects to restore the commitment that are laid causes had of had the option to show that their foundations legitimately advantage people in general. One of the significant reasons for the foundations demonstration of 2006 has been Public-advantage necessity. Every single beneficent association in the United Kingdom must have the option to show and give proof that they have had the option to effectively profit general society. In England and Wales, there are very nearly 600,000 associations which incorporates around 200,000 enrolled magnanimous associations which to not fall under the benefit division. The UK has consistently been known for having a solid custom of altruistic exercises. Different associations which are generally regul ar all through the world have current concerns and look to cause a benefit though altruistic associations to have been around throughout the previous 400 years in England and has been continually attempting to change the territory of open advantages. Anyway over the most recent 400 years, the general public in the UK has experienced various significant changes end there for altruistic should be side by side with the changing cultural examples in the UK. The deliberate part has assumed a significant job in the causes of the UK. They have consistently been the subject of surveys by the administration and have worked in close organization with neighborhood and focal governments. The Charities Act Of 2006 has consequently had the option to give the intentional associations a vastly improved lawful system for completing

Sample Short Answer Essay for a College Application

Test Short Answer Essay for a College Application The Common Application no longer requires a short answer exposition from all candidates, however numerous schools keep on including the short answer as a major aspect of an enhancement. The short answer paper brief regularly states something like this: Briefly expand on one of your extracurricular exercises or work encounters. Schools like this kind of inquiry since it offers their candidates the chance to recognize an action that is significant to them and to clarify why it is important. This data can be valuable to universities with all encompassing affirmations as they attempt to recognize understudies who will carry intriguing aptitudes and interests to the grounds network. Test Short Answer Essay Christie composed the accompanying example short answer exposition to expound upon her affection for running: It is the least complex of developments: right foot, left foot, right foot. It is the least complex of activities: run, unwind, relax. For me, running is both the most fundamental and the most mind boggling action I act at whatever day. While my body acclimates to the difficulties of rock ways and steep slopes, my psyche is allowed to float, to filter through whatever requirements arranging or arranging the up and coming days assignments, a contention with a companion, some bothering pressure. As my lower leg muscles slacken and my breathing subsides into its profound musicality, I am ready to discharge that pressure, overlook that contention, and set my brain all together. Also, at the halfway point, two miles into the course, I stop at the ridge vista neglecting my little town and the encompassing forests. For one minute, I stop to tune in to my own solid heartbeat. At that point I run once more. Study of the Short Answer Essay The creator has concentrated on an individual action, running, no history-production accomplishment, group triumph, world-changing social work, or even a formal extracurricular action. In that capacity, the short answer article doesn't feature any sort of momentous achievement or individual ability. Be that as it may, consider what this short answer article reveals the writer is somebody who can discover delight in the least complex of exercises. She is somebody who has discovered a compelling route for managing pressure and discovering harmony and balance in her life. She uncovers that she is on top of her self and her modest community condition. This one little section gives us the feeling that the creator is an astute, delicate, and solid individual. In a short space, the paper uncovers the development of the essayist she is intelligent, articulate, and adjusted. These are on the whole elements of her character that won't run over in her arrangements of evaluations, test scores, and extracurricular exercises. They are additionally close to home characteristics that will be alluring to a school. The composing is additionally strong. The exposition is tight, clear, and elaborate without being over-composed. The length is a perfectâ 823 characters and 148 words. This is a run of the mill length limit for a short-answer paper. All things considered, if your school is requesting only 100 words or something longer, make certain to adhere to their directions cautiously. Job of Essays and Your College Application Remember the job of any expositions, even short ones, that you submit with your school application. You need to introduce an element of yourself that isnt promptly evident somewhere else in your application materials. Uncover some concealed intrigue, energy, or battle that will give the confirmations people an increasingly point by point representation of yourself. The school has requested a short article since it has comprehensive affirmations; as such, the school attempts to assess the entire candidate through both quantitative (grades, test scores, rank) and subjective (papers, meet, extracurricular exercises). A short answer exposition gives the school a valuable window into the candidates interests. Christie prevails on this front. For both the composition and the substance, she has composed a triumphant short answer paper. You might need to investigate another case of aâ good short answer on working at Burger Kingâ as well as take in exercises from aâ weak short answer on soccerâ and aâ weak short answer on business enterprise. When all is said in done, in the event that you follow the exhortation on composing a triumphant short answer and maintain a strategic distance from basic short answer botches, your article will fortify your application and help make you an alluring contender for confirmation.

ERG11 in Drug-resistant of C. Krusei

ERG11 in Drug-safe of C. Krusei Erg11 changes and up-guideline in clinical itraconazoleresistant disconnects of Candida krusei Some C. krusei detaches were safe the antifungal medications. Changes including T939C, T642C and A756T were found in ERG11 of C. krusei. ERG11 was exceptionally communicated in safe C. krusei strains.. Unique Target We meant to give light for better comprehension of ERG11 quality in tranquilize opposition components in Candida krusei (C. krusei). Techniques C. krusei strains were separated from patients in the Dermatology from Jan 2010 to May 2013. Defenselessness tests, including 5-fluorocytosine (5-FC), amphotericin B (AMB), voriconazole (VCR), fluconazole (FLC) and itraconazole (ITR), was performed by stock microdilution strategy as indicated by the National Committee for Clinical Laboratory Standards M27-A2. Separates were isolated into powerless strains and safe strains dependent on their weakness to ITR. Transformations in the ERG11 quality arrangement were distinguished utilizing PCR enhancement and quality sequencing. Articulation levels of ERG11 were estimated by continuous PCR. Contrasts of ERG11 articulation levels between powerless strains and safe strains were thought about by two-followed Student t test. Results A sum of 15 C. krusei strains were acquired, among which 8.0, 6.0 and 3.0% were impervious to FCA, ITR and 5-FC, individually, though all secludes were seen as vulnerable to AMB and VRC. Three equivalent codon replacements were found in ERG11among all the C. krusei strains, including T939C, T642C and A756T. Articulation level of ERG11 was fundamentally higher in safe C. krusei strains (1.34  ± 0.08) than that in helpless C. krusei strains (0.94  ± 0.14) (t = 3.74, P Ends Our investigation shows that point transformations went with the overexpression of ERG11 may be engaged with the atomic systems of medication opposition in C. krusei. Catchphrases: ERG11; medicate obstruction; Candida krusei; change; overexpression. Presentation Candida species are pathogenic microorganisms for fundamental and nearby pioneering diseases and the fourth driving reason for nosocomial circulation system contaminations overall [1]. As of late, an expanding number of diseases because of Candida krusei has been seen [2]. C. krusei by and large causes contaminations among immunocompromised patients, particularly those experiencing Human immunodeficiency infection (HIV)- AIDS and hematological malignancies [3]. Death rates among such patients with C. krusei fungemia are accounted for to be as high as 60-80% [4]. Additionally, the expanding utilization of immunosuppressive medications has unavoidably expanded the danger of C. krusei disease, and C. krusei has positioned in fifth spot among all the types of Candida [5, 6]. C. krusei has been viewed as a multidrug-safe (MDR) parasitic pathogen by the explanation of its natural protection from fluconazole (FLC) just as its extensive decrease in helplessness to flucytosine and amphotericin B (AMB) [2]. Protection from these antifungal medications is a significant issue among patients with intense myelogenous leukemia, neutropenia as well as basically sick, since these medications are much of the time utilized for prophylaxis of C. krusei disease [7]. In this way, a superior comprehension of obstruction components in C. krusei was earnestly expected to viably forestall and control diseases brought about by C. krusei. It has been accounted for that different systems are associated with medicate opposition in C. krusei , including overexpression of a few qualities, for example, multidrug transporters (encoded by CDR1, CDR2, and MDR1), which lead to diminished intracellular amassing of FLC. These days, an expanding proof recommended that adjustments and overexpression of the ERG11 quality, which codes the objective catalyst cytochrome P450 lanosterol 14î ±-demethylase, are significant opposition component in C. krusei [8, 9]. Be that as it may, the rare data accessible with respect to ERG11 quality transformation and quality articulation in the medication safe strains makes C. krusei protection from azoles ineffectively comprehended [10]. In the current investigation, we assessed the powerlessness profiles of 15 C. krusei segregates, examined the potential changes in the ERG11 quality grouping of C. krusei strains, and further identified the differentially communicated degrees of ERG11 among defenseless and safe disconnects of C. krusei. We meant to give light for better comprehension of atomic systems in tranquilize opposition of C. krusei. Techniques 2.1 Fungal strains and media The strains utilized in this examination were segregated from patients in the Dermatology of the Second Hospital of Shanxi Medical University from Jan 2010 to May 2013. The standard strain, Candida krusei ATCC 6258, was bought from parasites and contagious infection investigate focal point of Peking University and remembered for each trial for quality control. C. Krusei were kept up on agar YPD medium (2% peptone, 1% yeast remove, 2% dextrose) and put away in our Fungi Laboratory. RPMI 1640 medium with L-glutamate (Sigma, St. Louis, Mo.) was utilized as prescribed for vulnerability examines and cradled to pH 7.0 with 0.165 M morpholinepropanesulfonic corrosive (MOPS). 2.2 Susceptibility tests The helplessness measures of the separates was acted in 96-well polystyrene microtiter plates by stock microdilution strategy portrayed in the National Committee for Clinical Laboratory Standards M27-A2 (NCCLS) [11]. The antifungal medications including 5-fluorocytosine (5-FC), amphotericin B (AMB), voriconazole (VCR), fluconazole (FLC) and itraconazole (ITR), were acquired from their particular makers and utilized for helplessness tests. MIC was characterized as the centralization of the medication that decreased the parasite development by 80% contrasted with that developed without the medication. The interpretive measures for defenselessness to the above medications were distributed by the NCCLS and recorded in Table 1. Tests were partitioned into defenseless strains and safe strains dependent on their helplessness to ITR. 2.3 PCR intensification and grouping arrangement of ERG11 quality To intensify ERG11 quality, genomic DNA was right off the bat segregated from C. krusei cells utilizing UNIQ-10 Column Genomic DNA Isolation Kit (Sangon Biotech, Shanghai, China) as indicated by the manufacturer’s guidance and utilized as a format for enhancement of the ERG11 qualities. Explicit groundworks of ERG11 (Table 2) were planned by Primer 3 [12], in light of the accessible grouping data of C. Krusei ERG11 quality (GI:163311561) at the National Center for Biotechnology Information (NCBI). The PCR enhancement of ERG11 quality was directed utilizing 2  µl of genomic DNA, 2  µl explicit forward and invert groundworks (50  µmol/L) and Taq PCR Master Mix (TIANGEN, Beijing, China). The PCR condition was set as denaturation for 5 min at 94  °C, trailed by 35 cycles: 94  °C for 30 s, 55  °C for 30 s and 72  °C for 30 s, and a last advance of stretching (72  °C for 8 min). PCR items were then isolated and measured on a 1.5% agarose gel by electrophoresis, and p ictured under UV light in the wake of recoloring with ethidium bromide. Effectively intensified PCR items were sent for sequencing (Invitrogen, Shanghai, China). To confirm the point transformations, sequencing results were lined up with the reference succession of C. Krusei ERG11 quality (GI:163311561) utilizing BLAST (Basic Local Alignment Search Tool) program in NCBI. 2.4 Real-time PCR examination For quantitative ongoing PCR investigation, absolute RNA was removed from C. krusei societies with a Yeast RNAiso Kit (TaKaRa, Dalian, China) and conversely translated to cDNA with PrimeScript RT Master Mix (TaKaRa, Dalian, China) as indicated by the guidelines of the maker. For the ERG11 target qualities and GAPDH reference quality, a preliminary pair were planned with Primer 5.0 program (Table 2). Continuous PCR was prepared with a 25- µl volume containing the accompanying reagents: 12.5  µl of SYBR ® Premix Ex TaqTM II (TaKaRa, Dalian, China), 2  µl of absolute RNA test, 1â µl of every preliminary pair at a grouping of 10  µM and refined water up to the last volume. Tests were exposed to an underlying advance at 95  °C for 5 min, trailed by 40 cycles every one of which comprised of 10 s at 95  °C and 30 s at 60  °C. Liquefying bends were recorded each 5 s during the 65-95  °C by PCR speaker. Fluorescence information (Ct) in every response were gathered and were broke down with the Rotor-Gene Q Series Software 2.0.2 programming. A 2ã ¢- ³Ã£ ¢- ³Ct calculation was applied to investigate relative articulation levels of ERG11 at powerless strains and safe strains. 2.5 Statistical investigation Factual investigation was performed utilizing SPSS 17.0 programming (SPSS incà ¯Ã‚ ¼Ã…'Chicagoà ¯Ã‚ ¼Ã…'US). All information were introduced as mean  ± standard deviation (SD). The two-followed Student t test was led to look at the distinctions of ERG11 articulation levels between helpless strains and safe strains. A p-esteem Results Antifungal susceptibilities of C. krusei confines A sum of 15 C. krusei strains were secluded from clinical examples during Jan 2010 to May 2013 in our research facility, among which 14 disconnects were from pee and 1 from hydrothorax (Table 3). Table 4 shows the paces of azole opposition for these C. krusei secludes. Among 15 C. krusei separates, 8.0, 6.0 and 3.0% were impervious to FCA, ITR and 5-FC, individually, while all disconnects were seen as vulnerable to AMB and VRC. At last, by utilizing a MIC ≠¥ 1  µg/ml to characterize protection from the investigational ITR, the 15 disconnects included 6 that were safe and 9 that were helpless. Mutational investigation in ERG11of C. krusei disconnects DNA part with predictable length was effectively enhanced from C. krusei disconnects (Figure 1). Grouping arrangement indicated three equal codon replacements in ERG11among all the C. krusei strains, including T939C, T642C and A756T (Figure 2). Among the three equivalent transformations, T642C and A756T just pre

Management and personal development Essay Example | Topics and Well Written Essays - 500 words

The executives and self-improvement - Essay Example This examination will start with the MBTI types. The MBTI Inventory measure individual across FOUR measurements: Introvert [I] - Extrovert [E]; Intuition [N] - Sensing [S]; Feeling [F] - Thinking [T]; Perception [P] - Judging [J]. ISTJ: Serious, calm, procure accomplishment by fixation and exhaustiveness. Down to earth, efficient, self evident truth, coherent, reasonable and reliable. Make sure that everything is efficient. Assume liability. Make up their own personalities about what ought to be cultivated and progress in the direction of it consistently, paying little mind to fights or interruptions. ISFJ: Quiet, agreeable, capable and upright. Work devotedly to meet their commitments. Loan security to any extend or gathering. Careful, meticulous, precise. Their inclinations are generally not specialized. Can show restraint toward vital subtleties. Steadfast, kind, insightful, worried about how others feel. INFJ: Succeed by steadiness, inventiveness, and want to do whatever is requi red or needed. Put their earnest attempts into their work. Unobtrusively commanding, principled, worried for other people. Regarded for their firm standards. Prone to be respected and followed for their unmistakable dreams with regards to how best to serve the benefit of all. INTJ: Have unique personalities and extraordinary drive for their own thoughts and purposes. Have a long-run vision and rapidly find important examples in outside occasions. In fields that intrigue to them, they have a fine capacity to arrange work and bring it through. Distrustful, basic, free, decided, have elevated expectations of capability and performance.â ... MBTI TYPES ISTJ Serious, calm, win accomplishment by fixation and careful quality. Down to earth, systematic, obvious certainty, sensible, practical and reliable. Make sure that everything is efficient. Assume liability. Make up their own personalities about what ought to be cultivated and progress in the direction of it consistently, paying little heed to fights or interruptions. ISFJ Quiet, agreeable, dependable and upright. Work devotedly to meet their commitments. Loan steadiness to any extend or gathering. Careful, meticulous, precise. Their inclinations are generally not specialized. Can show restraint toward important subtleties. Faithful, thoughtful, discerning, worried about how others feel. INFJ Succeed by constancy, inventiveness and want to do whatever is required or needed. Put their earnest attempts into their work. Discreetly powerful, honest, worried for other people. Regarded for their firm standards. Liable to be respected and followed for their reasonable dreams wi th regards to how best to serve the benefit of everyone. INTJ Have unique personalities and extraordinary drive for their own thoughts and purposes. Have long-extend vision and rapidly find important examples in outside occasions. In fields that intrigue to them, they have a fine capacity to sort out a vocation and bring it through. Distrustful, basic, free, decided, have elevated requirements of capability and execution. ISTP Cool spectators †tranquil, saved, watching and dissecting existence with confined interest and surprising flashes of unique amusingness. Normally inspired by circumstances and logical results, how and why mechanical things work and in arranging realities utilizing intelligent standards. Exceed expectations at getting profoundly of a reasonable issue and finding the arrangement. ISFP Retiring, discreetly neighborly, touchy,

Organization Behavior Example

Organization Behavior Example Organization Behavior â€" Article Example > Report on Leadership Constructs that Influence Innovative Behavior in employeesIntroductionThe case study is about the leadership constructs that influence innovative behavior in employees. It vividly delineates all the traits that predispose employees to embrace innovation. Finally, it concludes by highlighting the limitations that the researchers experienced as they undertook the study and how further study can be done to have more reliable results. This report will find out what really is discussed in the case and relate it to other studies. It will begin by defining leadership and innovation, discussion of the case’s problems, goals and concerns, critique of the case and finally make conclusions. Definition of leadership and innovation Theo Haimann defines leadership as the process by which an executive imaginatively directs, guides and influences the work of others in attaining specified goals. In essence, leadership is a process that involves influencing others to do a giv en task or tasks in a desired way in order to achieve anticipated outcomes. On the other hand, innovation, as put by the Merriam-Webster Dictionary is the process of coming up with new concepts or products that arise from people’s ideas and the commercialization thereof. So, leadership constructs that influence innovative behavior in employees are the types of leadership activities that can be done in order to encourage employees to come up with ideas that can be commercialized. Innovation undergoes two phases: creative and application phases. In the creative phase, only ideas are produced whereas in the application phase the ideas are applied to bear something of value. The problem/situation/concern in the caseThe issue being raised in the case study is how leaders can influence innovative behavior in employees. Assumptions made in the caseThe overriding assumption in the case is that it is only leadership that influences employees’ innovative behavior. A critical examination brings to fore that there are other numerous factors that may induce employees to innovate. The case study also made the assumptions that all leaders are the same in both the knowledge intensive services and other industries which is not the case. Goals of each stakeholderIn the context of innovation in any organization the following are the goals of each immediate stakeholder: EmployeesInnovation to employees is aimed at earning rewards in both financial and material. To get recognition from their superiors is also one of the goals. Leaders/managersThe managers encourage innovativeness in employees so as to produce better products to be competitive in the market by commanding a large market share. CustomersThey embrace innovation in employees so as to be guaranteed new products that can satisfy their emerging tastes and preferences. OwnersThey have a goal of seeing their investments growing and be guaranteed the going concern of the organization. Evidence relevant to innovationIt is very evident from the case that the definition of leadership (the process by which an executive imaginatively directs, guides and influences the work of others in attaining specified goals) comprise the following aspects:

LinkedIn and College Admissions

LinkedIn and College Admissions September 28, 2012 There is an article out today in US News World Report about LinkedIn and college admissions. Authored by Menachem Wecker, the article discusses a new feature on LinkedIn in which folks can endorse the skills of others. For instance, if you think that a former employee was a very good programmer, you can endorse that former employee on LinkedIn as a skilled programmer. Apparently, according to the US News World Report article, users can add up to 50 skills on their LinkedIn profiles. LinkedIn and college admissions are two different worlds. There is no need to have a LinkedIn profile as you seek to gain admission to highly selective colleges. The Founder of Ivy Coach, Bev Taylor, is quoted in the article with regard to the value of this new feature in highly selective college admissions. And by value, we mean valueless because this new feature will have no impact on highly selective college admissions. LinkedIn is for job seekers. Its for folks who work. Its not for teenagers who babysit on a summer evening or lifeguard at the local YMCA. Endorsements of skills on LinkedIn are as meaningless to college admissions counselors as an endorsement from your states senator who has never met you. That doesnt impress college admissions counselors and, in fact, can hurt your candidacy. Just think about it from the perspective of a college admissions counselor: This kid thought Id be impressed by an endorsement from Scott Brown? Has Scott Brown even met this kid? No. Oy vey. So dont do that. You dont need to have a LinkedIn profile as a high school student. What kinds of experiences are you going to listthat youre a member of Key Club? Give us a break. LinkedIn is for the working world. It has nothing to do with college admissions and thats the end of the story. While youre here, check out this post on Social Media and College Admissions.

Byzantine-Seljuk Wars and the Battle of Manzikert

The Battle of Manzikert was fought on August 26, 1071, during the Byzantine-Seljuk Wars (1048-1308). Ascending to the throne in 1068, Romanos IV Diogenes worked to restore a decaying military situation on the Byzantine Empires eastern borders. Passing needed reforms, he directed Manuel Comnenus to lead a campaign against the  Ã¢â‚¬â€¹Seljuk Turks with the goal of regaining lost territory. While this initially proved successful, it ended in disaster when Manuel was defeated and captured. Despite this failure, Romanos was able to conclude a peace treaty with Seljuk leader Alp Arslan in 1069. This was largely due to Arslans need for peace on his northern border so that he could campaign against the Fatimid Caliphate of Egypt. Romanos Plan In February 1071, Romanos sent envoys to Arslan with a request to renew the peace treaty of 1069. Agreeing, Arslan began moving his army into Fatimid Syria to besiege  Ã¢â‚¬â€¹Aleppo. Part of an elaborate scheme, Romanos had hoped that the treaty renewal would lead Arslan away from the area allowing him to launch a campaign against the Seljuks in Armenia. Believing that the plan was working, Romanos assembled an army numbering between 40,000-70,000 outside Constantinople in March. This force included veteran Byzantine troops as well as Normans, Franks, Pechenegs, Armenians,  Ã¢â‚¬â€¹Bulgarians, and variety of other mercenaries. The Campaign Begins Moving east, Romanos army continued to grow but was plagued by the questionable loyalties of its officer corps including the co-regent, Andronikos Doukas. A rival of Romanos, Doukas was a key member of the powerful Doukid faction in Constantinople. Arriving at Theodosiopoulis in July, Romanos received reports that Arslan had abandoned the siege of Aleppo and was retreating east towards the Euphrates River. Though some of his commanders wished to halt and await Arslans approach, Romanos pressed on towards Manzikert. Believing that the enemy would approach from the south, Romanos split his army and directed Joseph Tarchaneiotes to take one wing in that direction to block the road from Khilat. Arriving at Manzikert, Romanos overwhelmed the Seljuk garrison and secured the town on August 23. Byzantine intelligence had been correct in reporting that Arslan had abandoned the siege of Aleppo but failed in noting his next destination. Eager to deal with the Byzantine incursion, Arslan moved north into Armenia. In the course of the march, his army shrank as the region offered little plunder. The Armies Clash Reaching Armenia in late August, Arslan began maneuvering towards the Byzantines. Spotting a large Seljuk force advancing from the south, Tarchaneiotes elected to retreat west and failed to inform Romanos of his actions. Unaware that nearly half his army had departed the area, Romanos located Arslans army on August 24 when Byzantine troops under Nicephorus Bryennius clashed with the Seljuks. While these troops successfully fell back, a cavalry force led by Basilakes was crushed. Arriving on the field, Arslan dispatched a peace offer which was quickly rejected by the Byzantines. On August 26, Romanos deployed his army for battle with himself commanding the center, Bryennius leading the left, and Theodore Alyates directing the right. The Byzantine reserves were placed to the rear under the leadership of Andronikos Doukas. Arslan, commanding from a nearby hill, directed his army to form a crescent moon-shaped line. Commencing a slow advance, the Byzantine flanks were struck by arrows from the wings of the Seljuk formation. As the Byzantines advanced, the center of the Seljuk line fell back with the flanks conducting hit and run attacks on Romanos men. Disaster for Romanos Though capturing the Seljuk camp late in the day, Romanos had failed to bring Arslans army to battle. As dusk neared, he ordered a withdrawal back towards their camp. Turning, the Byzantine army fell into confusion as the right wing failed to obey the order to fall back. As gaps in Romanos line began to open, he was betrayed by Doukas who led the reserve off the field rather than forward to cover the armys retreat. Sensing an opportunity, Arslan began a series of heavy assaults on the Byzantine flanks and shattered Alyates wing. As the battle turned into a rout, Nicephorus Bryennius was able to lead his force to safety. Quickly surrounded, Romanos and the Byzantine center were unable to break out. Aided by the Varangian Guard, Romanos continued the fight until falling wounded. Captured, he was taken to Arslan who placed a boot on his throat and forced him to kiss the ground. With the Byzantine army shattered and in retreat, Arslan kept the defeated emperor as his guest for a week before allowing him to return to Constantinople. Aftermath While Seljuk losses at Manzikert are not known, recent scholarship estimates that the Byzantines lost around 8,000 killed. In the wake of the defeat, Arslan negotiated a peace with Romanos before permitting him to depart. This saw the transfer of Antioch, Edessa, Hierapolis, and Manzikert to the Seljuks as well as the initial payment of 1.5 million gold pieces and 360,000 gold pieces annually as a ransom for Romanos. Reaching the capital, Romanos found himself unable to rule and was deposed later that year after being defeated by the Doukas family. Blinded, he was exiled to Proti the following year. The defeat at Manzikert unleashed nearly a decade of internal strife which weakened the Byzantine Empire and saw the Seljuks make gains on the eastern border.